New research indicates that people who come off new GLP-1 drugs like semaglutide or tirzepatide can put back on shed pounds much more quickly than those who halt conventional diet and exercise programs.
Findings released in a prominent health publication shows that while overweight people often shed substantial amounts of their body weight while on the medication, the weight is regained at an estimated rate of nearly a kilo each month after stopping.
"Users purchasing these treatments must be aware of the danger of rapid rebound weight gain when the treatment ends," stated expert Dr. Susan Jebb.
That rate of recovery means a reversion to original weight in about one and a half years.
Comparing Therapies
The research, which reviewed 37 of trials involving over 9,000 of patients, compared the results of the injectable medications with conventional dieting.
Scientists note that individuals who shed pounds through diet and exercise typically have a less rapid weight regain—around 100 grams monthly—after stopping.
Understanding the Fast Regain
Doctors suggest the way of the drugs accounts for the accelerated regain.
These medications copy a natural hormone called glucagon-like peptide-1, which controls appetite.
"Sustained high doses of the hormone concentrations far above than normal could lead to the system to generate a reduced amount of its endogenous hormone, and may also diminish responsiveness to its actions," explained Dr. Adam Collins, a dietetics expert.
"Withdrawal of this hormone supplement results in hunger is unsuppressed, making binge eating a significant risk."
An Ongoing Condition?
Health authorities suggest the jabs for people with obesity-related medical conditions, accompanied by recommended diet and exercise modifications.
Professionals argue that, given the high risk of relapse, the therapy might need to be long-term.
This view is echoed by pharmaceutical companies, who note that the findings "underscore the persistent character of excess weight," akin to managing conditions like high blood pressure.
Patient Experiences
Users who have come off the jabs explain a powerful resurgence of appetite.
"It was like something flipping and I was suddenly extremely hungry," described one woman.
This difficulty is exacerbated if users have not established lasting dietary or behavioural changes during therapy.
Growing Adoption
Figures show that millions of adults in the UK have tried these injections in the past year, with interest continuing to grow.
- Use is greater among females compared to men.
- The 40s and 50s demographic shows the greatest usage rates.
- A large proportion access the medications through private healthcare rather than the NHS.
Ultimately, experts stress that while these medications are powerful agents for shedding pounds, they are not a magic cure and maintained weight loss likely depends on combined lifestyle changes.
